Evaluation of the pathogenicity of Pseudomonas aeruginosa isolates to strains of mice under stressful conditions

Pseudomonas aeruginosa (Pa) is an opportunistic pathogen that threatens the health, especially in immunocompromised individuals. survives everywhere, including a shuttle of spaceflights. Survival and starvation Pa water probably increase or decrease degree pathogenicity virulence, but it not well discovered. To promote our understanding mechanisms long-term survival water, investigations on kinetics its to mice are under investigation laboratory. Data has shown conditions can lead (i) for over 15 years water; (ii) distinct changes colony morphology, loss pigmentation. This study also aimed determine clinical environmental isolates starved conditions. We hypothesized results different curves, morphological, may enhance mice. Mice infected with showed lesser death rate than non-starved isolates. project compared susceptibility BALB/c, C57BL/6J, DBA/2 J lung infection. Our data shows vulnerability DBA/2J was high BALB/c C57BL/6J. Hindlimb-unloading increased strains. Lung infection differential rate, highest caused by Overall, exits reduced mortality